diff --git a/netbox/dcim/models/cables.py b/netbox/dcim/models/cables.py
index e14e20bfb..9835e13f8 100644
--- a/netbox/dcim/models/cables.py
+++ b/netbox/dcim/models/cables.py
@@ -657,6 +657,16 @@ class CablePath(models.Model):
         origin_ids = [decompile_path_node(node)[1] for node in self.path[0]]
         origin_model.objects.filter(pk__in=origin_ids).update(_path=self.pk)
 
+    def delete(self, *args, **kwargs):
+        # Mirror save() - clear _path on origins to prevent stale references
+        # in table views that render _path.destinations
+        if self.path:
+            origin_model = self.origin_type.model_class()
+            origin_ids = [decompile_path_node(node)[1] for node in self.path[0]]
+            origin_model.objects.filter(pk__in=origin_ids, _path=self.pk).update(_path=None)
+
+        super().delete(*args, **kwargs)
+
     @property
     def origin_type(self):
         if self.path:
diff --git a/netbox/dcim/signals.py b/netbox/dcim/signals.py
index 97200662b..dd9b7a0a6 100644
--- a/netbox/dcim/signals.py
+++ b/netbox/dcim/signals.py
@@ -170,6 +170,8 @@ def nullify_connected_endpoints(instance, **kwargs):
         # Remove the deleted CableTermination if it's one of the path's originating nodes
         if instance.termination in cablepath.origins:
             cablepath.origins.remove(instance.termination)
+            # Clear _path on the removed origin to prevent stale connection display
+            model.objects.filter(pk=instance.termination_id, _path=cablepath.pk).update(_path=None)
         cablepath.retrace()
 
 
diff --git a/netbox/dcim/tests/test_cablepaths.py b/netbox/dcim/tests/test_cablepaths.py
index 1bd613e3b..08c807280 100644
--- a/netbox/dcim/tests/test_cablepaths.py
+++ b/netbox/dcim/tests/test_cablepaths.py
@@ -2806,7 +2806,6 @@ class LegacyCablePathTests(CablePathTestCase):
         interface2 = Interface.objects.create(device=self.device, name='Interface 2')
         interface3 = Interface.objects.create(device=self.device, name='Interface 3')
 
-        # Create cables 1
         cable1 = Cable(
             a_terminations=[interface1],
             b_terminations=[interface2, interface3]
@@ -2838,6 +2837,10 @@ class LegacyCablePathTests(CablePathTestCase):
             is_active=True
         )
 
+        # Verify _path is cleared on removed interface (#21127)
+        interface3.refresh_from_db()
+        self.assertPathIsNotSet(interface3)
+
     def test_401_exclude_midspan_devices(self):
         """
         [IF1] --C1-- [FP1][Test Device][RP1] --C2-- [RP2][Test Device][FP2] --C3-- [IF2]